Dennis M Klinman Selected Research

CPG-oligonucleotide

1/2021	CpG Oligonucleotides as Vaccine Adjuvants.
1/2018	Blockade of TNFR2 signaling enhances the immunotherapeutic effect of CpG ODN in a mouse model of colon cancer.
10/2015	Intrapulmonary Delivery of CpG Microparticles Eliminates Lung Tumors.
11/2014	Clinical evaluation of CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases and cancer.
2/2014	Recent progress concerning CpG DNA and its use as a vaccine adjuvant.
1/2014	Combination therapy targeting toll like receptors 7, 8 and 9 eliminates large established tumors.
1/2014	TLR-9 agonist immunostimulatory sequence adjuvants linked to cancer antigens.
8/2012	Effect of CpG ODN on monocytic myeloid derived suppressor cells.
6/2012	The counter regulatory response induced by CpG oligonucleotides prevents bleomycin induced pneumopathy.
2/2012	Intratumoral injection of CpG oligonucleotides induces the differentiation and reduces the immunosuppressive activity of myeloid-derived suppressor cells.

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Dennis M Klinman Research Topics

Disease

31	Neoplasms (Cancer) 01/2021 - 09/2002
17	Inflammation (Inflammations) 01/2022 - 08/2002
16	Infections 12/2019 - 06/2002
9	Communicable Diseases (Infectious Diseases) 01/2021 - 09/2002
8	Pneumonia (Pneumonitis) 09/2016 - 11/2002
6	Autoimmune Diseases (Autoimmune Disease) 12/2014 - 10/2004
6	Anthrax 12/2009 - 07/2004
4	Hypersensitivity (Allergy) 01/2021 - 10/2003
3	Lung Neoplasms (Lung Cancer) 01/2018 - 02/2013
3	Lung Injury 09/2016 - 10/2004
3	Virus Diseases (Viral Diseases) 08/2012 - 03/2003
2	Carcinogenesis 01/2022 - 05/2011
2	Sepsis (Septicemia) 01/2020 - 05/2008
2	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/2018 - 06/2012
2	Glomerulonephritis 09/2014 - 02/2005
2	Silicosis 05/2014 - 06/2008
2	Wounds and Injuries (Trauma) 06/2011 - 11/2010
2	Shock 05/2011 - 04/2005
2	Asthma (Bronchial Asthma) 10/2003 - 11/2002
2	Arthritis (Polyarthritis) 06/2003 - 08/2002
2	Leishmaniasis 05/2003 - 02/2002
1	Melanoma (Melanoma, Malignant) 01/2022
1	Bites and Stings (Sting) 01/2021
1	Proteinuria 01/2019
1	Disease Progression 01/2019
1	Colonic Neoplasms (Colon Cancer) 01/2018
1	Colitis 09/2017
1	Lupus Nephritis 01/2017
1	Critical Illness (Critically Ill) 09/2016
1	Ventilator-Induced Lung Injury 09/2016
1	Septic Shock (Toxic Shock Syndrome) 03/2016
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 10/2015
1	Brain Ischemia (Cerebral Ischemia) 01/2015
1	Uveitis 01/2015
1	Brain Injuries (Brain Injury) 01/2015
1	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/2015
1	Stroke (Strokes) 01/2015

Drug/Important Bio-Agent (IBA)

30	CPG-oligonucleotideIBA 01/2021 - 02/2002
26	OligodeoxyribonucleotidesIBA 01/2018 - 06/2002
16	VaccinesIBA 01/2021 - 01/2004
15	OligonucleotidesIBA 01/2021 - 05/2004
13	CytokinesIBA 01/2019 - 11/2002
8	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 06/2002
7	Vaccine AdjuvantsIBA 01/2016 - 06/2002
6	AntigensIBA 01/2014 - 06/2002
5	Proteins (Proteins, Gene)FDA Link 01/2021 - 06/2002
4	Toll-Like Receptors (Toll-Like Receptor)IBA 12/2019 - 07/2006
4	Toll-Like Receptor 9IBA 01/2018 - 08/2005
4	LigandsIBA 01/2018 - 11/2006
4	ChemokinesIBA 05/2011 - 06/2004
3	InterferonsIBA 01/2021 - 01/2015
3	Anti-Bacterial Agents (Antibiotics)IBA 01/2020 - 03/2009
3	Silicon Dioxide (Silica)FDA LinkGeneric 01/2018 - 06/2008
3	AllergensIBA 04/2004 - 07/2003
2	InflammasomesIBA 01/2022 - 01/2015
2	Oxygen (Dioxygen)IBA 01/2020 - 01/2015
2	Toll-Like Receptor AgonistsIBA 12/2019 - 05/2015
2	CarcinogensIBA 01/2018 - 05/2014
2	SmokeIBA 01/2018 - 05/2014
2	InterleukinsIBA 01/2015 - 01/2011
2	Cancer VaccinesIBA 01/2014 - 05/2011
2	Recombinant ProteinsIBA 04/2007 - 06/2002
2	Interleukin-12 (IL 12)IBA 11/2006 - 11/2002
2	Immunoglobulin G (IgG)IBA 10/2006 - 02/2005
2	DNA VaccinesIBA 09/2006 - 07/2006
2	Anthrax Vaccines (Vaccines, Anthrax)IBA 06/2006 - 07/2004
2	Bacterial DNAIBA 12/2003 - 08/2002
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/2003 - 03/2003
1	Pattern Recognition ReceptorsIBA 01/2022
1	DNA receptor (receptor, DNA)IBA 01/2021
1	Interferon Regulatory Factor-3 (Interferon Regulatory Factor 3)IBA 01/2021
1	Interferon Type IIBA 01/2021
1	cyclic guanosine monophosphate-adenosine monophosphateIBA 01/2021
1	Oncogene Proteins (Oncogene Protein)IBA 01/2020
1	AutoantibodiesIBA 01/2019
1	Interleukin-6 (Interleukin 6)IBA 01/2018
1	Type II Tumor Necrosis Factor ReceptorsIBA 01/2018
1	Albumin-Bound Paclitaxel FDA Link 12/2017
1	Evans Blue (Blue, Evans)FDA Link 12/2017
1	Synthetic Vaccines (Recombinant Vaccines)IBA 12/2017
1	AlbuminsIBA 12/2017
1	Subunit VaccinesIBA 12/2017
1	LipopolysaccharidesIBA 09/2017
1	Dextran SulfateIBA 09/2017
1	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2017
1	Methylprednisolone FDA LinkGeneric 01/2017
1	Interleukin-4 (Interleukin 4)IBA 01/2017
1	hen egg lysozymeIBA 01/2017
1	AutoantigensIBA 01/2017
1	interstitial retinol-binding proteinIBA 01/2015
1	Multiprotein ComplexesIBA 01/2015
1	Phosphotransferases (Kinase)IBA 01/2015
1	Leucine (L-Leucine)FDA Link 01/2015
1	Messenger RNA (mRNA)IBA 01/2015
1	Glucose (Dextrose)FDA LinkGeneric 01/2015

Therapy/Procedure

12	Immunotherapy 01/2020 - 09/2002
10	Therapeutics 01/2020 - 12/2003
1	Mechanical Ventilators (Ventilator) 09/2016
1	General Anesthesia 09/2016
1	Artificial Respiration (Mechanical Ventilation) 09/2016